Barbiturates can induce hepatic microsomal enzymes leading to elevated metabolism and diminished anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people stabilized on anticoagulant therapy might involve dosage adjustments if barbiturates are included to or withdrawn from their dosage regimen
pentobarbital will reduce the level or result of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Caution with use in the course of surgical procedures or methods in young children young than three yr or in Expecting Women of all ages throughout their 3rd trimester
Induction of microsomal enzymes by this drug, may perhaps shorten the fifty percent-life of doxycycline for so long as 2 weeks right after barbiturate therapy discontinued; keep an eye on medical response to doxycycline carefully if each medicines administered concurrently
pentobarbital will lower the level or outcome of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unidentified.
pentobarbital will minimize the level or influence of parecoxib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
pentobarbital will decrease the level or impact of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will lower the extent or outcome of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, not enough efficacy or, possibly, advancement of the withdrawal syndrome in a affected person who may have developed Bodily dependence to fentanyl.
pentobarbital will minimize the level or result of levoketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will reduce the extent or result of sufentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will minimize the extent or outcome of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Lessened AUC of tramadol plus the Energetic metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducers
pentobarbital will minimize the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. The efficacy of hormonal contraceptives could be lowered.
pentobarbital will minimize the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.
Contraindicated (one)pentobarbital will reduce the extent or impact of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 check here metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers can result in lowered serum concentrations and lack of antimalarial efficacy